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中国癌症防治杂志 ›› 2014, Vol. 6 ›› Issue (1): 56-59.doi: 10.3969/j.issn.1674-5671.2014.01.13

• 临床研究 • 上一篇    下一篇

鼻咽癌患者调强放疗对早期认知功能的影响

  

  1. 广西医科大学研究生学院;广西壮族自治区人民医院认知睡眠中心;广西医科大学附属肿瘤医院放疗科
  • 出版日期:2014-03-25 发布日期:2014-04-10
  • 通讯作者: 李 龄 E-mail:lilingmoon99@163.com

Influence of intensity-modulated radiotherapy for nasopharyngeal carcinoma on cognitive function

  • Online:2014-03-25 Published:2014-04-10

摘要: 目的 探讨调强放疗对鼻咽癌患者放疗后早期认知功能的影响。方法 前瞻性分析2012年12月至2013年5月经病理活检确诊为鼻咽癌并接受调强放疗的初治患者52例,在CT定位图像上分别勾画左右侧颞叶,从剂量体积直方图(DVH)获取其受照射的剂量。采用DN-认知评估系统(DN-cognitive assessment system,DN-CAS)评价患者放疗前后的认知功能,并用配对t检验进行分析和比较。结果 患者左侧颞叶、右侧颞叶的平均受照射剂量分别为(17.5±7.3) Gy、(18.2±6.8) Gy。鼻咽癌患者放疗后在DN-CAS量表中的计划、同时性加工、注意、继时性加工分量表的标准分与放疗前相似(P>0.05)。结论 鼻咽癌患者调强放疗后早期的认知功能并未发生明显改变,但放疗后的长期影响值得关注。

关键词: 鼻咽肿瘤, 放射疗法, 调强放疗, 认知功能

Abstract:  Objective To explore the influence of intensity-modulated radiotherapy(IMRT) on cognitive function in patients with nasopharyngeal carcinoma(NPC). Methods Between December 2012 and May 2013, patients with pathologically diagnosed NPC scheduled to receive IMRT were included.Dose-volume histograms of the temporal lobes were obtained for every patient, and the Das Naglieri Cognitive Assessment System(DN-CAS) was used to assess cognitive function before and after radiotherapy.Differences in cognitive function between patients were analyzed using the paired t-test. Results Mean radiation dose was(17.5±7.3)Gy to the left temporal lobe and(18.2±6.8)Gy to the right temporal lobe. Standardized scores on all DN-CAS subtests(Planning, Attention, Simultaneous, and Successive cognitive processes) were similar before and after radiotherapy(P>0.05). Conclusions IMRT did not induce any acute changes in cognitive function of NPC patients. Future studies with longer follow-up should further evaluate the poten-tial effects of radiotherapy on the cognitive function of NPC patients.

Key words: Nasopharyngeal neoplasm, Radiotherapy, Intensity-modulated, Cognitive function